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Moreover, another study indicated that the following a diet with high omega-3 and low omega-6 fatty acids in comparison to a diet with low omega-6 had desirable effects on pain, quality of life, and antinociceptive lipid mediators in migraine patients (136)

It stimulates the synthesis of key ECM components, including collagen I and III, elastin, and various glycosaminoglycans (GAGs), by signaling through pathways such as the TGF-/SMAD cascade

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