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This finding holds significant importance, noting that phase 3 studies have typically excluded patients with a history of psychiatric disorders, resulting in a lack of reference data for understanding the long-term consequences of GLP-1 RAs use in patients with obesity

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Although sample sizes remain small, the consistency of results across studies underscores the potential of integrated metabolic-psychiatric approaches [41]

In vitro and preclinical in vivo experiments in arthritis have uncovered weight-loss-independent anti-inflammatory and chondroprotective properties of GLP-1RAs