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1 Introduction Neurodegenerative diseases (NDs) are of serious concern as they developed surreptitiously, progressively, and often irreversible with a high social burden

Heavy metals encompass both essential elements for life activities (such as iron, copper, and zinc) and toxic elements harmful to organisms (such as lead, cadmium, and arsenic) (Yu G

In honor of patient#1, the investigators named this novel ACOX1-mediated disease Mitchell Syndrome (distinct from Mitchell's disease, Erythromelalgia)

Systemic options like dupilumab [20] and tralokinumab are approved by FDA for moderate-to-severe cases, however age limitations occur [21]