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The anti-atrophy mechanism of PCHP involved maintaining protein metabolism homeostasis in the gastrocnemius muscle through the IL-6/signal transducer and activator of transcription 3 (STAT3)/cathepsin L (CTSL) and Diacylglycerol kinase (DGK)/the forkhead box O-class (FoxO)/Atrogin1 signaling axis, mediating the ubiquitin-proteasome and autophagy-lysosome systems, and downregulating the accumulation of ceramide via sphingomyelin phosphodiesterase 2 ( 5.1.7 Anti-obesity PCHP could markedly reverse insulin resistance as indicated by a reduction in obesity markers, enhanced leptin and fasting blood glucose levels, and improvements in serum lipid profiles

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Weir GC, Bonner-Weir S

M.LazrakA.AhmadI.AggarwalS.et al (2025)

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