In addition, since GLP-1 is also produced locally within pancreatic islets, and its expression increases with the progress of diabetes development 22,23,24,25,26,27 , linagliptin may exert insulinotropic and glucagonostatic effects directly on the islets by elevating local GLP-1 concentrations
[DOI] [PMC free article] [PubMed] [Google Scholar] Willard FS, Wainscott DB, Showalter AD, Stutsman C, Ma W, Cardona GR, Zink RW, Corkins CM, Chen Q, Yumibe N, Agejas J, Cumming GR, Minguez JM, Jimnez A, Mateo AI, Castao AM, Briere DA, Sloop KW, Bueno AB
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A new drug delivery system that paints weight loss medications directly onto antibodies could allow patients to use just one-fourth of their typical GLP-1 dose while achieving better, longer-lasting results, according to research presented Sunday at the American Chemical Societys spring meeting in San Diego
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