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Probiotics and electrolytes GLP-1 medications alter gut motility, which can affect the microbiome

While most other semaglutide-based GLP-1 drugs like Ozempic are not explicitly FDA-cleared for weight loss, many physicians will prescribe one off-label if they believe its the best option for a patients health profile and weight loss needs

49 Further evaluation on a double-blind, randomized phase 1 clinical trial in 98 patients with T2DM on current management with metformin revealed that Danuglipron was generally well tolerated and associated with minimal side effects such as nausea, dyspepsia, and vomiting comparable with the ones observed with the use of injectable GLP-1RA

DPN pain: Orals: Duloxetine, pregabalin, tapentadol ER

2018;362:k601