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3.0.CO;2-F Pouny, Y., Rapaport, D., Mor, A., Nicolas, P., and Shai, Y., Biochemistry , 1992, vol

NON-CONTRACEPTIVE HEALTH BENEFITS The following non-contraceptive health benefits related to the use of oral contraceptives are supported by epidemiologic studies which largely utilized oral contraceptive formulations containing estrogen doses exceeding 0.035 mg of ethinyl estradiol or 0.05 mg of mestranol

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Moreover, factors such as fluid dynamics, pH, and disease-induced pathological alterations in the brains microenvironment (i.e., changes in enzymatic activity, impairment in vascular function, and inflammation) can significantly influence drug distribution and efficacy (Nance et al., 2022)

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