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Available data suggest that under hypoxichypoglycemic conditions of ischemic stroke, oligodendrocytes are particularly vulnerable owing to their high iron load, low levels of reduced glutathione, elevated oxidative metabolic rate, abundant lipid and sphingolipid content, and the high permeability of their glutamate receptors (S

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These cells express low -SMA and do not secrete collagens, suggesting that they are in a precursor state