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The 2025 KDIGO commentary highlights growing evidence that GLP-1RAs, particularly semaglutide, offer clinically meaningful kidney and CV protection in people with CKD, including those without DM

The paper also speaks directly to the lack of innovation in addiction medicine, which is the focus of CASPRs policy work: Since the FDA approval of the first AUD medication (disulfiram) in 1951, only 2 medications (naltrexone and acamprosate) have received subsequent FDA approval for AUD

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When rapid weight loss is medically necessary : Before bariatric surgery, for joint replacement candidacy, or when weight directly threatens cardiovascular health

A study published in JAMA found that individuals using GLP-1 receptor agonists had a higher incidence of gallbladder-related problems compared to those on placebo