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A: Multiple pathways: GH receptor upregulation, nitric oxide system modulation, VEGF-promoted angiogenesis, and direct inflammatory cytokine interaction

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Histopathological examination using H&E and AB-PAS staining revealed severe pathological changes in the colonic epithelium of DSS-treated mice

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More than one in eight retatrutide-treated participants were completely pain-free at the end of the trial