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however, this methodology has inherent limitations.182 Furthermore, the guidelines do not differentiate recommendations based on the indication for GLP-1RAs use (eg, diabetes versus obesity) or the specific surgical procedure.74 In cases where patients report gastrointestinal symptoms on the day of surgery, postponement of the procedure is recommended.74 If patients do not adhere to the discontinuation recommendations, the Task Force advises implementing comprehensive gastric protective measures or considering the preoperative assessment of gastric volume via ultrasound

One alternative explanation for GLP1 neuroprotection that has recently received experimental support is that systemic GLP1 or GLP1 receptor agonists improve cerebrovascular parameters and thus increase glucose and oxygen supply to the brain

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