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20 Although most research has focused on intravesical (administered directly into the bladder) use of these compounds, one uncontrolled trial in 252 subjects with IC/BPS found treatment with an oral supplement providing 600 mg chondroitin sulfate, 480 mg glucosamine sulfate, and 40 mg hyaluronic acid, plus 600 mg quercetin and 80 mg rutin (anti-inflammatory flavonoids), per day led to reduced symptom severity during more than 12 months of monitoring and was more effective in those who had more severe symptoms at the beginning of the trial