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The two-year data demonstrates that the body does not develop tolerance, the weight does not inevitably rebound while on treatment, and the metabolic improvements persist over the long term

Standard tests for cardiovascular risk can be considered indicators of arterial thrombosis risk

The needle must pass through tiny blood vessels to reach this layer, and when a vessel is nicked, blood leaks into surrounding tissue, creating a bruise

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In the SUSTAIN-6 trial with semaglutide, the primary outcome (the first occurrence of a composite of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke) occurred in 6.6% of patients receiving semaglutide and in 8.9% of patients on placebo (HR 0.74