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Two authors (SE and NE) independently assessed the risk of bias in studies across six domains: random sequence generation (selection bias for controlled trials), allocation concealment (selection bias for controlled trials), blinding of participants and personnel (performance bias), blinding of outcome assessment (detection bias), incomplete outcome data (attrition bias), and selective reporting (reporting bias) ( Evidence synthesis We adopted systematic methods, including textual descriptions and tabulation, using the Review Manager (RevMan) (Version 5.4

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Iin situ hybridization (ISH) RNAscope procedure was performed on ileum and colon samples exactly as described before 27 using the ACD procedure and reagents from the RNAscope 2.5 HD chromogenic detection Kit (FastRed)