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Arch Biochem Biophys 503:24852 Zhu X, Gallogly MM, Mieyal JJ, Anderson VE, Sayre LM (2009) Covalent cross-linking of glutathione and carnosine to proteins by 4-oxo-2-nonenal

42 Stabilizing cardiolipin or enhancing its translocation improves mitochondrial clearance and reduces oxidative stress in heart failure models, 43 while enzymes involved in cardiolipin metabolism, such as tafazzin, represent additional therapeutic opportunities

Comprehensive Support : Motivation and counseling to help patients navigate the social and emotional hurdles of dietary change

It notes these medications were originally developed for type 2 diabetes and have shown cardiovascular benefits independent of weight loss

Type 2 Diabetes: Rosenstock et al., 2023 (Lancet) Rosenstock, Fras, Jastreboff, and colleagues reported a phase 2, randomized, double-blind, placebo- and active-controlled, parallel-group trial in The Lancet in 2023 [5]