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doi:10.1016/S0140-6736(24)00469-0

Individual responses vary enormously

Mounjaro is not insulin

From a pathophysiological perspective, my first thought is that this could reflect an indirect effect on peripheral nerve sensitivity, possibly related to: rapid shifts in glucoselipid metabolism, changes in nerve conduction due to electrolyte fluctuations, or even a centrally mediated effect, considering GLP-1 receptor expression in the CNS