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Glutamine is technically a nonessential amino acid
This means MOTS-c not only works through biochemical pathways like AMPK, but also by directly adjusting gene expression to bolster the cells defense against oxidative stress
Individuals with increased oxidative stress due to lifestyle or environmental factors
Am J Pathol 1976;85:20928
Although targeting macropinocytosis could be a key strategy for overcoming resistance to glutamine uptake blockade, further studies are necessary to examine whether macropinocytosis can overcome tumor cell resistance to glutamine antimetabolites or GLS inhibitors that target enzymes involved directly in glutamine metabolism
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