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doi:10.1016/j.ejogrb.2008.01.004 80

Figure 2 illustrates schematically some documented changes: rhythms of locomotor activity (rest-activity cycle), core body temperature, hormone secretion (e.g., melatonin at night, cortisol in the morning), SCN neuronal firing rate, and even daily metabolic indicators like plasma glucose all show diminished oscillation amplitudes in older adults compared to younger adults

Cardiac dysfunction may be associated with subclinical hypothyroidism, even when serum TSH is still in the normal range

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Iron homeostasis and the inflammatory response