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DPP-4 can also have signaling functions via interactions with the extracellular matrix (90), and it was therefore speculated that the DPP-4 inhibitor might have improved insulin sensitivity by interfering with this process in some way rather than by blocking the enzymatic activity per se (79, 89)

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Moreover, high development costs, long regulatory timelines, and the limited market size for GBM deter commercial investment (Chen et al

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#VCT220 #Gimaglipron #GLP1 #DrugDiscovery #ChinaBiotech Decoding VCT220 (CX11, gimaglipron): China's Oral GLP-1 Contender Alongside Orforglipron and HRS-7535 Following positive Phase 3 topline results in Chinese adults with obesity, VCT220 (Gimaglipron, CX11), discovered by Vincentage Pharma and now being developed globally by CORXEL Pharmaceuticals, has emerged as one of China's leading oral small-molecule GLP-1 receptor agonists, with NDA submission planned for obesity and potential expansion into type 2 diabetes