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While anti-obesity medications suppress appetite, Schmidt said they dont inherently instill healthy habits

However, glucagon also: Increases energy expenditure: Glucagon promotes thermogenesis and fat oxidation Targets the liver directly: The liver has no GLP-1 or GIP receptors but is rich in glucagon receptors Reduces liver fat: Glucagon receptor activation may ease oxidative stress in liver mitochondria Provides anti-fibrotic benefits: Improved fat oxidation can improve mitochondrial function When combined with GLP-1 and GIP agonism, the glucagon components blood sugar effects appear to be counterbalanced while its metabolic benefits are retained

The American Diabetes Association Standards of Care recommends regular assessment of glycemic control, weight trends, and medication tolerance in patients receiving GLP-1 receptor agonists

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"We found that fewer than 1 in 4 patients remained on a GLP-1 medication after a year," says Dr