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only 10% is free or bound to albumin Functions Cofactor for several enzymes involved in carbohydrate and amino acid metabolism: Pyruvate dehydrogenase (connects glycolysis to citric acid cycle): pyruvate acetyl-CoA Alpha-ketoglutaric acid dehydrogenase (citric acid cycle): -Ketoglutarate succinyl-CoA Transketolase (HMP shunt) D-xylulose-5-P D-ribose-5-P Glyceraldehyde-3-P D-xylulose-5-P Branched-chain ketoacid dehydrogenase Enzymes thiamine is a cofactor for: Thiamine PATs your Back

Recent advances have attempted to target NAMPT at suboptimal doses in combination with other compounds and developing good expected activity