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Two studies received funding from pharmaceutical companies and thus were deemed to be at high risk for other bias [28, 39]

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e , Left, volcano plot showing relative fold change (log 2 ) in whole cell metabolite abundance versus log 10 (P value) from HEK293T cells expressing a sgRNA targeting intergenic region or sgRNA targeting SLC33A1

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Most of what we know comes from animal studies, small case reports and registry data, rather than large clinical studies in humans