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GLUT1 reductions exacerbate Alzheimers disease vasculo-neuronal dysfunction and degeneration

Chronic persistent hypoxia is recurrent in chronic lung diseases where O 2 levels remain constantly low, while chronic IH is characteristic of obstructive sleep apnea, characterized by an intermittent pattern of episodes of hypoxia and reoxygenation [133]

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Its safety, efficacy, and pharmacological effects in humans have not been established

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