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In experiments involving mouse models exposed to CS, exposure to GHK-Cu was linked to a potential decrease in the production of pro-inflammatory cytokines, including interleukin-1 (IL-1) and tumor necrosis factor- (TNF-), found in bronchoalveolar lavage fluidfluid used to capture cells and soluble factors from the airways and lung tissues

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Following these early observations, the up-regulation of plant GST genes has often been used as an indicator of oxidative stress and HR in plant-bacterium interactions (Alvarez et al., 2000)

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