For example, in both PE and FGR studies, the authors used models obtained from intraperitoneal injection of compounds such as NG-Nitro-L-arginine methyl ester (L-NAME), desoxycorticosterone acetate (DOCA) [57,58,152] or by genetic knockout models [153]
12 Initial obesity-focused trials of tirzepatide tended to be more inclusive, only excluding patients with a history of known drug abuse, alcohol abuse, or psychiatric disorder that may preclude the patient from following and completing the protocol
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