Patients prescribed GLP-1RAs displayed a significantly reduced hazard ratio for the diagnosis of intestinal obstruction compared with patients prescribed insulin at 1, 3, and 5 years
R., Morokuma K., Zakrzewski V
Key points: Leverage platform data from similar biologics Eliminate redundant toxicology studies Combine endpoints within the same study Use in vitro and computational models earlier Align with the 3Rs principle (Replacement, Reduction, Refinement) Important step toward more ethical and efficient ocular drug development
"Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor gamma in human skeletal muscle cells"
Gracias a la presencia de L-carnitina en el organismo, el mecanismo de accin de obtencin de energa a partir de grasas acumuladas se ve favorecido y, con ello, se evita que la produccin de energa pase al siguiente nivel de obtencin de materia prima que sera la degradacin de aminocidos antes comentada