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Moderately likely: gastrointestinal issues Degraded semaglutide can sometimes trigger gastrointestinal side effects that differ from the normal nausea many users experience during dose escalation

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No heterogeneity was observed among the studies ( I 2 = 0%, p = 0.84), leading to using a fixed-effect model for result reporting

This means it stimulates insulin release mainly when blood sugar is elevated, which lowers the chance of low blood sugar when taken on its own

GLP-1 medications solve this by using modified versions of the hormone that resist enzymatic breakdown, maintaining elevated levels for days or even a full week depending on the formulation