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Taken together, this also demonstrates that Fc-engineered human IgG variants with altered binding to FcRn behave differently in human and murine model systems, which highlights the importance of accounting for cross-species differences when studying Ab-based therapeutics and FcRn biology [101,102,103]
Energy-supporting peptides like SS-31 address mitochondrial dysfunction that contributes to autoimmune fatigue
This mechanism positions KPV as a promising candidate for intestinal inflammation therapy, providing targeted anti-inflammatory action while avoiding the systemic immunosuppression associated with conventional treatments
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