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Foundational Characterisation The synthesis and initial characterisation of Melanotan 1 by Hadley and Dorr at the University of Arizona established it as a potent, stable MC1R agonist with substantially enhanced in vivo bioactivity compared to native -MSH, and confirmed its capacity to stimulate melanogenesis in pre-clinical models

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Consequently, the inhibition of Gln metabolism is associated with elevated ROS levels, which in turn promotes apoptosis in tumor cells (44)

2022;45(Supplement_1):A4-A4