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Smokeless tobacco Smokeless tobaccocomposed of fermented plant materials, alkaline additives (e.g., sodium carbonate), and carcinogenic nitrosaminesdiffers fundamentally from combustible cigarettes and aerosolized ECs by delivering nicotine and toxins through direct mucosal contact rather than inhalation, a distinction that reshapes its biological interactions and uniquely perturbs oral microbial ecosystems through pH modulation, xenobiotic exposure, and epithelial barrier disruption

2 These rechargeable e-cigarettes, often called nd generation: vape pens these are comprised of a battery pen used with prefilled or refillable e-liquid cartridges that use free-base nicotine

Output: DC Barrel tip

Psychopharmacology (Berl) 223 : 159168

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