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22 When it is impaired, it results in an overproduction of mucus and slowing mucus clearance

Each of these components of e-cigarette vapour has been demonstrated to pose a risk to the cardiovascular system: a) nicotine can increase blood pressure and heart rate, or cause inflammation or stiffness in the arteries

Dose Area Product (DAP), is a multiplication of the dose and the area exposed, often expressed in Gy.cm2

While nicotine may feel calming in the short term, its largely due to relieving withdrawal symptoms

Ridge distribution analysis further showed a broader and higher variant frequency spectrum in T-B2B, consistent with an increased mutation load (Fig