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This research is a powerful reminder of the urgent need to address cigarette smoking as the leading preventable cause of death and disease in the UK. Join our commenting forum Join thought-provoking conversations, follow other Independent readers and see their replies Comments

Thats how Billy looks at his seven decades: as a series of lives running into one another, sometimes with a slow dissolve, sometimes with a smash cut

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The general activation pattern involving the brains reward circuitry also implies that use of ENDS may have a similar rewarding effect as traditional cigarettes