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Over time, this can lead to tolerance, where increasingly larger doses are necessary to achieve the medications initial effects, potentially leading to a physical dependence where the body expects the drug for normal function

Heres a timeline of what happens when you stop smoking tobacco: Within 20 minutes of your last smoke, your heart rate, typically elevated by nicotine use, drops back to a normal level

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Use of human induced pluripotent stem cell-derived cardiomyocytes to predict the cardiotoxicity potential of next generation nicotine products