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therefore, it is difficult to say with certainty how significant of a role nicotine and TS play in the pathogenesis of the disease

In a 6-month clinical study in the USA, smokers who switched from smoking cigarettes to predominant THS use showed significant improvements in clinical risk endpoints associated with O 2 delivery (decreased carboxyhaemoglobin levels), inflammation (reduced white blood cell count), and COPD (increased FEV 1 ), although their plasma nicotine levels remained similar to that in smokers