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New 4 th generation e-cigarettes like Juul and other pod mods contain high concentrations of nicotine about 5% or 59mg/ml Most of them also use nicotine salts, which can deliver a higher concentration without as much throat irritation as would be the case with the freebase nicotine used in earlier e-cigarettes

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Though the Marlboro Man campaign has evolved over time, the legacy of the original cowboy archetype remains a symbol of masculinity and adventure

Literature search strategy and study eligibility Literature was identified that described the pharmacokinetics and/or pharmacodynamics of cannabis or cannabinoids in humans

Role of Funding Sources This work was supported by the National Institutes of Health (NIH) and FDA Center for Tobacco Products (U54 CA229973 to A