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Dermatologist 65: 1067-1077 Mustoe TA et al (2005) International clinical recommendations on scar management

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A second trial, comparing normal subjects and subjects with moderate-to-severe renal impairment (GFR 30.9 10.8 mL/min) showed that after a single 150-mg dose of sustained-release bupropion, exposure to bupropion was approximately 2-fold higher in subjects with impaired renal function, while levels of the hydroxybupropion and threo/erythrohydrobupropion (combined) metabolites were similar in the 2 groups