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Pulmonary transfection of mtDNA by intratracheal instillation induced profound recruitment of neutrophils and expression of proinflammatory cytokines TNF- and KC (an IL-8 homologue) in C57BL/6 mice ( 2 by the mitochondria, leading to oxidation and inactivation of the ACO-2 substrate, and hence further accumulation of citrate to promote increased mtDNA synthesis

Thank you John Jensen

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