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These fibers can irritate the cells in the lung or pleura and eventually cause lung cancer or mesothelioma

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(EDIT: AliceD's answer also depicts the well-known staining of teeth, which are not keratinized, showing that the staining mechanism is likely a nonspecific adsorption of greasy things onto surfaces.) The stain can be fixed through the involvement of free radicals and other reactive species in cigarette smoke, like formaldehyde

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