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Cytotoxic effect of nicotine alone impairs regenerative ability of MSCs, but it only partly explains cytotoxic effects of cigarette smoke

Sympathetic nervous system activation (fight-or-flight) Nicotine can activate the sympathetic nervous system and increase catecholamine signaling, which may increase resting energy expenditure and activity-related energy expenditure (again described in the review on nicotines effects on energy balance)

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Smokers cough is particularly seen in long term chronic smokers who are addicted to the habit for a prolonged period of time