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Participants who had been categorized as smokers, abstainers from smoking, regular users of nicotine products or those who reduced smoking by 50%, called reducers provided saliva samples to analyze cotinine levels, a marker of tobacco smoke exposure found in saliva

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They also found that lower quality studiesranked using the Newcastle-Ottawa Scaletended to report positive associations and had greater between-study variance ( 2 = 0.2) while higher quality studies tended to report null findings and had lower between-study variance ( 2 = 0.01) [116]

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