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For instance, the extent of DNA double-strand breaks is reflected by the increase in H2AX, an early step in the DNA damage response (DDR) machinery [50]

Premature Aging Smoking accelerates the aging process, causing wrinkles, yellow teeth and dull skin

Because of shortened telomeres, smokers have an even greater risk of developing cancer and other diseases

Morsy MA, Khaled MM (2001) Direct electron paramagnetic resonance study of tobacco

The song that is the focus of this episode The Pretty Things Are Going To Hell is the work of an artist getting through the idea of becoming old and irrelevant, yet it harkens back to some of Bowies greatest works