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Further, smoking, which is known to increase the levels of receptors for nicotine in the brain, had this effect in both groups, although it was blunted in schizophrenia

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This makes the device a valid alternative for those who, while not yet ready to quit smoking entirely, want to move toward a less harmful choice and progressively reduce the risks associated with tobacco combustion

Although its mechanism of action is unclear, it seems to act as an antagonist at the nicotinic acetylcholine receptor 14,1

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