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Furthermore, differentially expressed genes (DEGs) in CON and NIC mice groups were identified based on the criteria of a log 2 -transformed fold change (FC) exceeding 0.25 and a p-value threshold of 0.01
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Cigarette smoking significantly affects several drug metabolizing enzymes and transporters, in addition to the well-known effects on cytochrome P450 (especially the CYP1A2 isoform)
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