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Furthermore, in an animal study, nicotine was shown to promote tumor growth, mainly by activating the -adrenoceptors and the subsequent expression of cyclooxygenase-2, prostaglandin E2, and VEGF in tumor tissues (79)

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Second, in 2009, the Chinese government implemented an adjustment in its tobacco tax structure in order to raise revenue, which effectively decreased the profit margin on the lower-priced cigarettes relative to higher-priced cigarettes.4 The government prohibited the resulting tax increase from being passed on directly to smokers

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