There are more than 1 10 14 microbial cells in the human intestine, which play important roles in physicochemical and physiological functions via their dynamic interaction with the host, including intestinal development, barrier integrity and function, metabolism, immunity, inflammation, and neurological signaling regulation (Turnbaugh et al., 2006), rheumatoid arthritis (Scher et al., 2020), systemic lupus erythematous (Zhang et al., 2019)
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