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In addition, it was found that cigarette smoke extract (CSE), a water-soluble tobacco smoke component, induces a moderate level of mitochondrial outer membrane permeabilization (MOMP) that does not trigger apoptosis, namely, minority MOMP, while also diminishing the mitochondrial membrane potential in endothelial cells

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Ohta et al., 2011

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29 Reducing smoking is essential to closing the gap in health outcomes