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The warnings feature textual statements with photo-realistic color images depicting some of the lesser-known, but serious health risks of cigarette smoking, including impact to fetal growth, cardiac disease, diabetes and more

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Previous clinical studies with small numbers of patients with schizophrenia reported that smokers had an approximately fivefold lower dose-corrected steady-state plasma olanzapine concentration and a lower decrease in the Brief Psychiatric Rating Scale-total score than non-smokers.8 ,9 Meanwhile, although the relationship between the clozapine concentration and clinical outcome is controversial,1012 it was also reported that smokers who were treated with clozapine suffered side effects (ie, auditory hallucinations, hallucinations, hypersalivation, drowsiness, clonic seizures, convulsions and unconsciousness) after smoking cessation.4 ,1316 Many studies about the effects of smoking on the disposition of olanzapine and clozapine have been undertaken, but no definitive agreement regarding the dose adjustment in clinical practice based on the patient's smoking status has been reached

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