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65% of patients who received systemic glucocorticoids had documentation by the clinical team that respiratory improvement was due to the use of glucocorticoids. The CDC has provided recommendations for physicians, which include initiating glucocorticoids when appropriate, but more rigorous study is needed to define which populations benefit most and the doses and durations needed

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The effects described in the report are in many cases, as in the aforementioned Swedish study, considered to be the effects of nicotine in high doses, often based on animal studies

Overall, the Hallmark gene set analysis suggests that DA vapor exposure results in changes in NHBECs similar to those observed in hypoxia leading to inflammation and compensatory TGF--mediated repair signatures