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The structure is an informal noun that originally referred to a vagrant or homeless person, later generalized in slang as a broad insult for someone perceived as useless or unwilling to contribute

In particular, cigarette smoke was found to induce alveolar macrophages and neutrophils to produce pro-inflammatory cytokines, reactive oxygen species, matrix metalloproteinases, and various chemokines 31

JAMA 2019;322:2095-103

10.1164/rccm.201510-2013PP Summary Keywords tobacco, neonatal exposure, teratogen, e-cigarettes, maternal smoking Citation Wells AC and Lotfipour S (2023) Prenatal nicotine exposure during pregnancy results in adverse neurodevelopmental alterations and neurobehavioral deficits