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A modified risk tobacco product (MRTP) was later approved by the FDA
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First-generation devices (cig-a-likes) were mostly found to have inefficient or negligible nicotine delivery
These contain wire and wicking material (usually cotton)
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![Cigarette smoking is associated with levels of the serotonin transporter in the brain: a [11C]DASB PET Study](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c13d/12095803/34d63b1cbd92/pyaf026_fig2.jpg)
